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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: SRF All Species: 25.76
Human Site: S221 Identified Species: 40.48
UniProt: P11831 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0.07
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P11831 NP_003122.1 508 51593 S221 L I Q T C L N S P D S P P R S
Chimpanzee Pan troglodytes XP_518487 508 51590 S221 L I Q T C L N S P D S P P R S
Rhesus Macaque Macaca mulatta XP_001093365 508 51688 S221 L I Q T C L N S P D S P P R S
Dog Lupus familis XP_852302 508 51510 S221 L I Q T C L N S P D S P P R S
Cat Felis silvestris
Mouse Mus musculus Q9JM73 504 51229 S217 L I Q T C L N S P D S P P R S
Rat Rattus norvegicus NP_001102772 504 51157 S217 L I Q T C L N S P D S P P R S
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001517936 150 15822
Chicken Gallus gallus Q90718 375 39146 Q101 R S D P T T D Q R M S A T G F
Frog Xenopus laevis P23790 448 46097 L174 K A L I Q T C L N S P D S P P
Zebra Danio Brachydanio rerio NP_001103996 539 55032 P209 D S P P R T D P S T D Q R M S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q24535 449 47603 Y174 R V K I K M E Y I D N K L R R
Honey Bee Apis mellifera XP_001120126 351 36852 S76 R G I K R T T S D V C Y D D S
Nematode Worm Caenorhab. elegans NP_492296 327 35027 E53 G R V K I K M E Y I N N K L R
Sea Urchin Strong. purpuratus XP_796790 410 43027 T136 G H V Y T F A T R K L Q P M I
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P11746 286 32783 N12 E E G T P T N N G Q Q K E R R
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.6 98.4 97.2 N.A. 96.4 96.6 N.A. 22.8 66.5 72.4 57.7 N.A. 35 33.4 28.7 33.8
Protein Similarity: 100 99.8 98.8 98 N.A. 97.4 97.6 N.A. 24 69.6 76.9 67.7 N.A. 48.8 40.3 41.1 45.6
P-Site Identity: 100 100 100 100 N.A. 100 100 N.A. 0 6.6 0 6.6 N.A. 13.3 13.3 0 6.6
P-Site Similarity: 100 100 100 100 N.A. 100 100 N.A. 0 13.3 0 13.3 N.A. 40 13.3 6.6 13.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. 23.4 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 33 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 20 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 26.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 7 0 0 0 0 7 0 0 0 0 7 0 0 0 % A
% Cys: 0 0 0 0 40 0 7 0 0 0 7 0 0 0 0 % C
% Asp: 7 0 7 0 0 0 14 0 7 47 7 7 7 7 0 % D
% Glu: 7 7 0 0 0 0 7 7 0 0 0 0 7 0 0 % E
% Phe: 0 0 0 0 0 7 0 0 0 0 0 0 0 0 7 % F
% Gly: 14 7 7 0 0 0 0 0 7 0 0 0 0 7 0 % G
% His: 0 7 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 40 7 14 7 0 0 0 7 7 0 0 0 0 7 % I
% Lys: 7 0 7 14 7 7 0 0 0 7 0 14 7 0 0 % K
% Leu: 40 0 7 0 0 40 0 7 0 0 7 0 7 7 0 % L
% Met: 0 0 0 0 0 7 7 0 0 7 0 0 0 14 0 % M
% Asn: 0 0 0 0 0 0 47 7 7 0 14 7 0 0 0 % N
% Pro: 0 0 7 14 7 0 0 7 40 0 7 40 47 7 7 % P
% Gln: 0 0 40 0 7 0 0 7 0 7 7 14 0 0 0 % Q
% Arg: 20 7 0 0 14 0 0 0 14 0 0 0 7 54 20 % R
% Ser: 0 14 0 0 0 0 0 47 7 7 47 0 7 0 54 % S
% Thr: 0 0 0 47 14 34 7 7 0 7 0 0 7 0 0 % T
% Val: 0 7 14 0 0 0 0 0 0 7 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 7 0 0 0 7 7 0 0 7 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _